The knowledge of God has been naturally implanted in the human mind.
Everyone, even the most "barbarous" or those in some tribe far from civilisation, have some sense of a deity "indelibly engraven on the human heart" says Calvin and this leaves them without excuse before Him. This is because God has "endued all men with some idea of his Godhead". No matter how much man may harden his heart in hatred against God, this sense of a deity "now and then breaks forth" and "gnaws" at his conscience. Calvin argues that, since we are "born and live for the express purpose of learning to know God" to fail to seek Him is to fail to live in line with the very purpose for which we were made.